Detection of Urinary Epithelial Sodium Channel (ENaC) Protein
نویسندگان
چکیده
منابع مشابه
Increased renal alpha-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy.
Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear. We first used a targeted proteomics approach and found that there were no changes in the protein abundance compared with virgin rats of the β or γ ENaC, type 3 Na(+)/H(+) exchanger (NHE3), bumetanide-sensitive cotrans...
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Amiloride-sensitive epithelial sodium channels constitute the rate-limiting step for sodium reabsorption in the distal part of the renal tubule, in the distal colon, in the ducts of several exocrine glands, and in the airways (Rossier et al., 1994). Until recently, the classification of the epithelial sodium channels was exclusively based on biophysical and pharmacological properties: sodium an...
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The epithelial sodium channel (ENaC) is a key element for the maintenance of sodium balance and the regulation of blood pressure. Three homologous ENaC subunits (alpha, beta and gamma) assemble to form a highly Na+-selective channel. However, the subunit stoichiometry of ENaC has not yet been solved. Quantitative analysis of cell surface expression of ENaC alpha, beta and gamma subunits shows t...
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Despite large changes in water and salt intake, the kidney is able to maintain the extracellular osmolarity and volume within narrow margins (Verrey et al., 2000). Such fine control requires specific factors or hormones ; among them, aldosterone and antidiuretic hormone (ADH) (vasopressin in mammals) play the key role. The main effector for the sodium balance is the epithelial sodium channel ex...
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ژورنال
عنوان ژورنال: American Journal of Clinical Medicine Research
سال: 2018
ISSN: 2328-4005
DOI: 10.12691/ajcmr-6-2-1