Detection of mobile colistin-resistance gene variants (<i>mcr-1</i>and<i>mcr-2</i>) in urinary tract pathogens in Bangladesh: the last resort of infectious disease management colistin efficacy is under threat

Background: Currently, colistin-resistant pathogens emerged has become a global health concern. This study assessed the distribution of mcr-1 to mcr-5 variants with phenotypic colistin-resistance in bacterial isolates from urinary tract infection (UTI) patients Bangladesh.Methods: A cross-sectional was conducted between April 2017 and March 2018 enroll uncomplicated UTI patients, 142 urine samples were analyzed. Uropathogens identified using API-20E biochemical panel 16s rRNA gene sequencing. Polymerase chain reactions detected mcr isolates. The colistin-susceptibility determined by Kirby–Bauer disc-diffusion method minimal inhibitory concentration (MIC) measurement.Results: combined carriage mcr-2 genes 11.4% (14/123) pathogens. mcr-positive include five Escherichia coli, three Klebsiella pneumoniae, Pseudomonas putida, two Enterobacter cloacae, one hormaechei. variant showed significantly higher colistin resistance MIC >16 µg/mL >128 (p< 0.001). Over 85% MDR phenomena.Conclusions: emergence clinical highly selective drug may lead lack treatment options for infectious diseases spread unaffected cohorts.