Detection of MDR1 single nucleotide polymorphisms C3435T and G2677T using real-time polymerase chain reaction: MDR1 single nucleotide polymorphism genotyping assay
نویسندگان
چکیده
منابع مشابه
Evaluation of G2677T/A polymorphism of MDR1 gene by polymerase chain reaction in Mazandaran province, Iran
The human MDR1 gene encodes for a P-glycoprotein (PGP), which acts as an efflux pump that transports a large variety of substrates from the inside of cells to the outside until protection against xenobiotics. The G2677T/A polymorphism in exon 21 is associated with PGP expression and function in humans. The present study was aimed to determine the frequencies of this polymorphism in a healthy po...
متن کاملFREQUENCY OF C3435 MDR1 AND A6896G CYP3A5 SINGLE NUCLEOTIDE POLYMORPHISM IN AN IRANIAN POPULATION AND COMPARISON WITH OTHER ETHNIC GROUPS
ABSTRACT Background: It is well recognized that different patients respond in different ways to medications. The inter-individual variations are greater than the intera- individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. The recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the ...
متن کاملevaluation of g2677t/a polymorphism of mdr1 gene by polymerase chain reaction in mazandaran province, iran
the human mdr1 gene encodes for a p-glycoprotein (pgp), which acts as an efflux pump that transports a large variety of substrates from the inside of cells to the outside until protection against xenobiotics. the g2677t/a polymorphism in exon 21 is associated with pgp expression and function in humans. the present study was aimed to determine the frequencies of this polymorphism in a healthy po...
متن کاملFrequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population.
The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as a gate-keeper against various kinds of xenobiotics. Several single nucleotide polymorphisms (SNPs) in the MDR1 gene that may influence PGP level and function have been identified. The aim of this study was to simultaneously analyze the three most important MDR1 SNPs, C3435T, G2677T/A and C1236T, in the Ser...
متن کاملFrequency of G2677T/A and C3435T polymorphisms of MDR1 gene in preeclamptic women.
OBJECTIVE Preeclampsia (PE) belongs to main causes of mortality rates of mothers, fetuses and new born children. Polymorphism of MDR1 gene is connected with reduction of P-glycoprotein expression in placenta and increased fetal exposure to xenobiotics. The aim of the study was to determine the frequency of C3435T and G2677T/A polymorphisms of MDR1 gene in pregnant women with preeclampsia. MAT...
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ژورنال
عنوان ژورنال: AAPS PharmSci
سال: 2002
ISSN: 1522-1059
DOI: 10.1208/ps040429