Detection of KRAS mutation using plasma samples in non-small-cell lung cancer: a systematic review and meta-analysis

Background The aim of this study was to investigate the diagnostic accuracy KRAS mutation detection using plasma sample patients with non-small cell lung cancer (NSCLC). Methods Databases Pubmed, Embase, Cochrane Library, and Web Science were searched for studies detecting in paired tissue samples NSCLC. Data extracted from each eligible analyzed MetaDiSc STATA. Results After database searching screening pre-defined criteria, 43 identified relevant data extracted. pooling 3341 patients, pooled sensitivity, specificity odds ratio 71%, 94%, 59.28, respectively. Area under curve summary receiver operating characteristic 0.8883. Subgroup analysis revealed that next-generation sequencing outperformed PCR-based techniques NSCLC, specificity, 73%, 82.60, Conclusion Compared tumor sample, showed overall good performance which could serve as surrogate when are not available.