Detection of Cold Pain, Cold Allodynia and Cold Hyperalgesia in Freely Behaving Rats
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چکیده
منابع مشابه
Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats
BACKGROUND Pain is elicited by cold, and a major feature of many neuropathic pain states is that normally innocuous cool stimuli begin to produce pain (cold allodynia). To expand our understanding of cold induced pain states we have studied cold pain behaviors over a range of temperatures in several animal models of chronic pain. RESULTS We demonstrate that a Peltier-cooled cold plate with +/...
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Hyperalgesia from an incisional pain is evoked by noxious stimuli (mechanical and cold). The present study was aimed to examine the effect of licofelone, a dual inhibitor of cyclooxygenases (COX-1/COX-2) and 5-lipoxygenase (5-LOX) against mechanical hyperalgesia and cold allodynia in the rat model of incisional pain. Mechanical hyperalgesia and cold allodynia was assessed employing Randall and ...
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Cold-triggered pain is essential to avoid prolonged exposure to harmfully low temperatures. However, the molecular basis of noxious cold sensing in mammals is still not completely understood. Here, we show that the voltage-gated Nav1.9 sodium channel is important for the perception of pain in response to noxious cold. Nav1.9 activity is upregulated in a subpopulation of damage-sensing sensory n...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2005
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-1-36