Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA)
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چکیده
منابع مشابه
BRAF Mutations in Iranian Papillary Thyroid Carcinomas
Papillary thyroid cancer or papillary thyroid carcinoma (PTC) is the most common thyroid cancer that is account for 80-90% of all thyroid cancer cases (Kimura et al., 2003; Xing et al., 2005; Yoon et al., 2013). This thyroid cancer is occasionally occurs in women aged 30-40 years old and it is also prevalent in children and patients whose exposed to radiation in head and neck area. These types ...
متن کاملBRAF overexpression is associated with BRAF V600E mutation in papillary thyroid carcinomas.
A common mutation in the BRAF gene, comprising the T1799A nucleotide transversion, which leads to the V600E amino acid substitution in the BRAF protein, has been observed in about 50% of papillary thyroid carcinomas (PTCs). However, BRAF protein expression has been rarely examined in such tumors. Clinical studies have shown important associations between BRAF mutation and clinical parameters in...
متن کاملCarcinomas and Thyroid Tumor Cell Lines High Prevalence of BRAF Gene Mutation in Papillary Thyroid
The RAS-RAF-MEK-ERK-MAP kinase pathway mediates the cellular response to extracellular signals that regulate cell proliferation, differentiation, and apoptosis. Mutation of the RAS proto-oncogene occurs in various thyroid neoplasms such as papillary thyroid carcinomas (PTCs), follicular thyroid adenomas and carcinomas. A second genetic alteration frequently involved in PTC is RET/PTC rearrangem...
متن کاملHigh prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.
The RAS-RAF-MEK-ERK-MAP kinase pathway mediates the cellular response to extracellular signals that regulate cell proliferation, differentiation, and apoptosis. Mutation of the RAS proto-oncogene occurs in various thyroid neoplasms such as papillary thyroid carcinomas (PTCs), follicular thyroid adenomas and carcinomas. A second genetic alteration frequently involved in PTC is RET/PTC rearrangem...
متن کاملBRAF mutation in papillary thyroid carcinoma.
BRAF mutation is the most common genetic alternation in thyroid cancer, particularly in papillary thyroid cancer (PTC). Excessive activation of BRAF/MAPK signaling pathway due to BRAF mutation plays a central role in the tumorigenesis and development of PTC. The association of BRAF mutation with poor clinicopathological characteristics of PTC further demonstrated the importance of the BRAF muta...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2006
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.1.02072