Detecting and targeting NTRK gene fusions in cholangiocarcinoma: news and perspectives
نویسندگان
چکیده
Cholangiocarcinomas (CCAs) are rare and aggressive tumors accounting for less than 1% of all malignancies worldwide approximately the 10–15% primary liver cancers [1]. Unfortunately, adv...
منابع مشابه
Detecting and visualizing gene fusions.
In recent years, gene fusions have gained significant recognition as biomarkers. They can assist treatment decisions, are seldom found in normal tissue and are detectable through Next-generation sequencing (NGS) of the transcriptome (RNA-seq). To transform the data provided by the sequencer into robust gene fusion detection several analysis steps are needed. Usually the first step is to map the...
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Rearrangements, or gene fusions, involving the ETS family of transcription factors are common driving events in both prostate cancer and Ewing sarcoma. These rearrangements result in pathogenic expression of the ETS genes and trigger activation of transcriptional programs enriched for invasion and other oncogenic features. Although ETS gene fusions represent intriguing therapeutic targets, tran...
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ژورنال
عنوان ژورنال: Expert review of precision medicine and drug development
سال: 2021
ISSN: ['2380-8993']
DOI: https://doi.org/10.1080/23808993.2021.1910023