Detecting amino acid preference shifts with codon-level mutation-selection mixture models
نویسندگان
چکیده
منابع مشابه
Untangling the Effects of Codon Mutation and Amino Acid Exchangeability
Determining the relative contributions of mutation and selection to evolutionary change is a matter of great practical and theoretical significance. In this paper, we examine relative contributions of codon mutation rates and amino acid exchangeability on the frequencies of each type of amino acid difference in alignments of distantly related proteins, alignments of closely related proteins, an...
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Models that explicitly account for the effect of selection on new mutations have been proposed to account for "codon bias" or the excess of "preferred" codons that results from selection for translational efficiency and/or accuracy. In principle, such models can be applied to any mutation that results in a preferred allele, but in most cases, the fitness effect of a specific mutation cannot be ...
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ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2019
ISSN: 1471-2148
DOI: 10.1186/s12862-019-1358-7