Detailed and atypical HLA‐E peptide binding motifs revealed by a novel peptide exchange binding assay

Identification of a Novel Tumor-Binding Peptide for Lung Cancer Through in-vitro Panning

Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...

Identification of a Novel Tumor-Binding Peptide for Lung Cancer Through in-vitro Panning

Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...

A Novel Lyn-Binding Peptide Inhibitor

Allosteric modulation of peptide ligand binding to Neuropeptide Y receptor Y1 revealed by fluorescence-based assay

MicroRNAs (miRNAs) are short, 22–25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3’-untranslated region (3’-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3’-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found th...

design of a novel metal binding peptide by molecular dynamics simulation to sequester cu and zn ions

heavy metal toxicity has serious adverse effects on the environment. the metal sequestering characteristics of a novel metal binding peptide (glu-cys) 11 gly+linker+hexahistidine (ec 11 :his 6 ) was investigated to determine if it can absorb cu 2+ or zn 2+ cations. molecular dynamics simulations were carried out using a model of 6 cu 2+ or zn 2+ and other ions enclosed in a fully hydrated simul...