Destruction of L Cells by Mengo Virus: Use of Interferon to Study the Mechanism

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Destruction of L cells by Mengo virus: use of interferon to study the mechanism.

Interferon, when added to L cells, inhibited the synthesis of infectious Mengo viral ribonucleic acid, hemagglutinins, and infectious virus by 85 to 95%. Serum-blocking antigens were also reduced by the action of interferon, but threefold excess amounts of these antigens accumulated in interferon-treated cultures above the amounts expected for the quantity of infectious virus that was produced ...

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Inhibition of Mengo virus by interferon.

Gauntt, Charles J. (The University of Texas, Austin), and Royce Z. Lockart, Jr. Inhibition of Mengo virus by interferon. J. Bacteriol. 91:176-182. 1966.-The inhibition of Mengo virus replication in L cells resulting from interferon was studied quantitatively. Interferon was titrated on L cells with Western equine encephalomyelitis (WEE) virus as the challenge virus. One protective unit (PU) of ...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 1968

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.2.6.567-575.1968