Desoxycorticosterone acetate and oestradiol dipropionate therapy in the newborn infant

Desoxycorticosterone Acetate

1. Desoxycorticosterone acetate (DCA) and NaCl, in the dosage employed in normal rats, caused renal and cardiac hypertrophy, characteristic changes in the renal tubular epithelium, atrophic changes in the subcapsular zone of the adrenal cortex, and serum electrolyte changes characterized by a rise in sodium and fall in potassium. 2. In rats rendered nephritic with a rabbit anti-rat-kidney serum...

Desoxycorticosterone Acetate and Wound Healing

The effect of desoxycorticosterone acetate (DCA) on the granulation tissue of healing and healed linear laparotomy wounds was studied in young adult male guinea pigs maintained on a complete diet and on a known intake of ascorbic acid. DCA induces the production of an excessive amount of granulation tissue, as evidenced by a relatively great number of fibroblasts and by a larger amount of groun...

A Model of the Respiratory System in the Newborn Infant

A dynamic mathematical model is presented which successfully simulates the respiratory control system of the newborn infant in different physiological conditions. The primary objective in constructing this model has been to provide a simulation aid in the investigation of maturation of the respiratory system, and the respiratory disorders during the newborn period, without the need for invasive...

The Combined Effect of Cortisone Acetate and Desoxycorticosterone Acetate in Adrenal- Ectomized Rats

In a previous report the authors have described the response of young adrenalectomized rats to desoxycorticosterone acetate (DCA) and to cortisone acetate (CA) when maintained on a diet severely restricted in sodium content (1). Daily injections of 2.5 mg. of DCA resulted in progressive weight gain and maintenance of normal blood pressure, while similar doses of CA were accompanied by rapid wei...

The effect of desoxycorticosterone acetate on water and electrolyte distribution.