Designing of Thiazolidin-4-one Pharmacophore using QSAR Studies for Anti-HIV Activity

Synthesis, Antimicrobial, Anticancer Evaluation and Qsar Studies of Thiazolidin-4-one Derivatives.

In this study, a novel series of 4-thiazolidinone derivatives (1-17) was synthesized and evaluated for its in vitro antimicrobial and anticancer potentials. N-(2-(5-(4-nitrobenzylidene)-2-(4-chlorophenyl)-4-oxothia- zolidin-3-ylamino)-2-oxoethyl) benzamide (7, pMICam = 1.86 µM/mL) was found to be the most active antimi- crobial agent. The anticancer study results demonstrated that N-(2-(5-(4-hy...

Chapter-8. Synthesis, antimicrobial, anticancer evaluation and QSAR studies of thiazolidin-4-one derivatives

3D-QSAR Studies on Thiazolidin-4-one S1P1 Receptor Agonists by CoMFA and CoMSIA

Selective S1P(1) receptor agonists have therapeutic potential to treat a variety of immune-mediated diseases. A series of 2-imino-thiazolidin-4-one derivatives displaying potent S1P(1) receptor agonistic activity were selected to establish 3D-QSAR models using CoMFA and CoMSIA methods. Internal and external cross-validation techniques were investigated as well as some measures including region ...

Classification of Anti-HIV Compounds using QSAR Studies

The Acquired Immunodeficiency Syndrome (AIDS) is one the most fatal disorders for which there have been no complete or successful chemotherapy yet. The pandemic spread of this disease has prompted an unprecedented scientific clinical effort to understand and propagate ways to combat it. Quantitative Structure–Activity Relationship (QSAR) study has been reportedly used to study topological indic...

synthesis and in-vitro anti-bacterial activity of new thiazolidin-4-one derivatives