منابع مشابه
Designer proteins in biotechnology
Introduction The structural and functional complexity of proteins as heteropolymeric polypeptide chains is based on diverse interactions between a variety of their hydrophobic, polar and ionizable side chains. These interactions occur in unliganded proteins as well as on association with ligands. This complexity makes it difficult to predict accurately the structure and function of a protein fr...
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Microorganisms are able to respond effectively to diverse signals from their environment and internal metabolism owing to their inherent sophisticated information processing capacity. A central aim of synthetic biology is to control and reprogramme the signal processing pathways within living cells so as to realise repurposed, beneficial applications ranging from disease diagnosis and environme...
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Ideally, the insulin therapy must aim at the creation of a near normal glycaemic profile without the barriers of unacceptable weight gain or hypoglycaemia. Provision of a flexible insulin regimen would further enhance adherence to the prescribed therapy and positively impact glycaemic control. Insulin degludec addresses many of the aspirations of ideal basal insulin. Long duration of action, fl...
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Efforts to generate biologically active proteins by de novo computational design have been limited to creating functional sites within pre-existing scaffolds. Procko et al. use an innovative computational design approach coupled with in-vitro-targeted evolution to produce a potent polypeptide inhibitor of a viral Bcl-2-like protein. This novel inhibitor triggers apoptosis of virus-infected cells.
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Recent progress in the design and selection of novel zinc finger proteins with desired DNA binding specificities now allows construction of tailor-made DNA-binding proteins that specifically recognize almost any predetermined DNA sequence. Such novel or "designer" zinc finger proteins with desired DNA binding specificities can serve as efficient transcription factors in various mammalian cell l...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2003
ISSN: 1469-221X,1469-3178
DOI: 10.1038/sj.embor.embor808