Design, synthesis, and discovery of 5-((1,3-diphenyl-1 H -pyrazol-4-yl)methylene)pyrimidine-2,4,6(1 H ,3 H ,5 H )-triones and related derivatives as novel inhibitors of mPGES-1

Anticancer Studies of Novel 2 , 4 - Disubstituted - 1 , 5 - Diphenyl - 1 H - Imidazole Derivatives

In the present work a series of novel 2,4-disubstituted -1, 5 -diphenyl substituted -1H-imidazole derivatives were screened for anticancer activity using human liver cancer cell line. Derivatives were evaluated for anticancer activities against Hep G2 (Human liver cancer) cell lines. Newly synthesized compounds A-IVn, A-IVo,B-IVb, B-IVc, B-IVd, and B-IVe showed highly significant cytotoxic acti...

Three-dimensional quantitative structure activity relationship approach series of 3-Bromo-4-(1-H-3-Indolyl)-2, 5-Dihydro-1H-2, 5- Pyrroledione as antibacterial agents

The use of quantitative structure–activity relationships, since its advent, has becomeincreasingly helpful in understanding many aspects of biochemical interactions in drug research.This approach was utilized to explain the relationship of structure with biological activity ofantibacterial. For the development of new fungicides against, the quantitative structural–activityrelationship (QSAR) an...

H.1 H.2 H.3 H.4

SYNTHESIS OF 1,4,8 - TRIHYDROXY- 9 (1 0 H) - ANTHRACENONE

The title compound has been synthesized starting from 2-methoxybenzdiethylarnide (1).

PREPARATION AND CHARACTERIZATION OF [Ni (MAP) ] ; H- MAP = 2- (METHYLAMINO) PYRIDINE H. Aghabozorg* and H. H. Monfared

We have recently synthesized [Ni (MAP) ] complex [H-MAP= 2- (methylamino) pyridine]. 2- (Methy1amino)pyridine reacts with MeLi in THF and generates the lithium salt (Li-MAP). Further reaction of NiCl with two equivalent of this ligand in THF leads to the formation of a dark red solution. Analytical data, molecular weight, and magnetic susceptibility of this complex confirm the formula [N...