Design principles underpinning the regulatory diversity of protein kinases
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Design principles underpinning the regulatory diversity of protein kinases
Protein phosphorylation in eukaryotes is carried out by a large and diverse family of protein kinases, which display remarkable diversity and complexity in their modes of regulation. The complex modes of regulation have evolved as a consequence of natural selection operating on protein kinase sequences for billions of years. Here we describe how quantitative comparisons of protein kinase sequen...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2012
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2012.0015