Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer
نویسندگان
چکیده
منابع مشابه
Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer.
Chimeric antigen receptor T (CAR-T) cells have demonstrated promising results against hematological malignancies, but have encountered significant challenges in translation to solid tumors. To overcome these hurdles, we have developed a switchable CAR-T cell platform in which the activity of the engineered cell is controlled by dosage of an antibody-based switch. Herein, we apply this approach ...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2016
ISSN: 1433-7851
DOI: 10.1002/anie.201601902