Design of stapled oxyntomodulin analogs containing functionalized biphenyl cross-linkers
نویسندگان
چکیده
منابع مشابه
A New Methodology for Incorporating Chiral Linkers into Stapled Peptides
Stapled peptides have arisen as a new class of chemical probe and potential therapeutic agents for modulating protein-protein interactions. Here, we report the first two-component i,i+7 stapling methodology that makes use of two orthogonal, on-resin stapling reactions to incorporate linkers bearing a chiral centre into a p53-derived stapled peptide. Post-stapling modifications to the chain were...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2019
ISSN: 0040-4020
DOI: 10.1016/j.tet.2018.11.060