منابع مشابه
Cytomegalovirus Protease Targeted Prodrug Development
Human cytomegalovirus (HCMV) is a prevalent virus that infects up to 90% of the population. The goal of this research is to determine if small molecular prodrug substrates can be developed for a specific HCMV encoded protease and thus achieve site-specific activation. HCMV encodes a 256 amino acid serine protease that is responsible for capsid assembly, an essential process for herpes virus pro...
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Being HIV–1–PR an essential enzyme in the viral life cycle, its inhibition can control AIDS. Because the folding of single domain proteins, like HIV–1–PR is controlled by local elementary structures (LES, folding units stabilized by strongly interacting, highly conserved amino acids) which have evolved over myriads of generations to recognize and strongly attract each other so as to make the pr...
متن کاملProdrug Design vs. Drug Design
A drug is defined as a substance which is used in the cure, relief, diagnosis, treatment, or prevention of disease. The development of any potential drug commences with the study of the biochemistry and physiology behind a disease for which pharmaceutical intervention is feasible [1]. Prodrug is a term that was first introduced by Albert to signify a pharmacologically inactive chemical moiety t...
متن کاملDesign and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor
In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...
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An investigational nucleoside analogue drug, viramidine, has recently emerged as a potentially safer alternative to ribavirin for the treatment of hepatitis C viral infection. We have reported that viramidine mainly functions as a prodrug of ribavirin that is enriched in the liver. This in vitro study further explores viramidine's activity against nucleoside phosphorylase, a host enzyme that is...
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ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1990
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.64.1386