Design of ECM Functionalized Polycaprolactone Aligned Nanofibers for Peripheral Nerve Tissue Engineering

Fabrication and cellular compatibility of aligned poly(hydroxy alkanoate) nanofibers for nerve tissue engineering

The ability to fabricate aligned nanofibers may open new avenues for the development of nerve regeneration using tissue engineering scaffolds. In this study, aligned poly(3-hydroxybutyrate)/poly(3-hydroxy butyrate-co-3-hydroxyvalerate) (PHB/PHBV) nanofibrous scaffolds were fabricated using electrospinning for the culture in vitro of Schwann cells (SCs) that physiologically assist in directing t...

Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering

Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

Poly(lactic acid) (PLA) Nanofibers for Bone Tissue Engineering

Bioactive peptide functionalized aligned cyclodextrin nanofibers for neurite outgrowth

Guidance of neurite extension and establishment of neural connectivity hold great importance for neural tissue regeneration and neural conduit implants. Although bioactive-epitope functionalized synthetic or natural polymeric materials have been proposed for the induction of neural regeneration, chemical modifications of these materials for neural differentiation still remain a challenge due to...

Design and fabrication of a nanofibrous polycaprolactone tubular nerve guide for peripheral nerve tissue engineering using a two-pole electrospinning system.

Nerve guidance conduits are considered to be the new generation of scaffolds designed for nerve disorders. A tubular construct with a highly aligned fibrous structure, mimicking the endoneurium layer surrounding inner axons of a nerve fascicle, is a suitable candidate for a nerve guide. In this paper a new approach for the fabrication of 3D tubular nerve guides is introduced using simulation of...