Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
نویسندگان
چکیده
منابع مشابه
Design of a biaxial mechanical loading bioreactor for tissue engineering.
We designed a loading device that is capable of applying uniaxial or biaxial mechanical strain to a tissue engineered biocomposites fabricated for transplantation. While the device primarily functions as a bioreactor that mimics the native mechanical strains, it is also outfitted with a load cell for providing force feedback or mechanical testing of the constructs. The device subjects engineere...
متن کاملSpecial Issue: Design of Bioreactor Systems for Tissue Engineering
Tissue engineering and, more broadly, regenerative medicine is moving into a phase where we are seeing potential therapies moving 'slowly but surely' from the laboratory into the clinic, i.e., from research to the clinic and into manufacturing. The numbers of cells required for cell therapy protocols can vary from tens of millions, to billions [1], and it is widely considered that such cell num...
متن کاملDevelopment of a novel bioreactor for the mechanical loading of tissue-engineered heart muscle.
OBJECTIVE In this study, we describe a novel bioreactor system to deliver controlled stretch protocols to bioengineered heart muscle (BEHM) constructs. Our primary objective was to evaluate the effect of mechanical stretch on the contractile properties of three-dimensional cardiac constructs in vitro. METHODS BEHMs were formed by culturing primary neonatal cardiac myocytes in a fibrin gel usi...
متن کاملTissue Engineering Bioreactor
pg. 2) Background (pg. 2-8) Alternative Design Descriptions (pg. 8-11) Final Design (pg. 11-13) References (pg. 13) Appendix A: Product Design Specifications (pg. 13-16)
متن کاملDesign and validation of a bi-axial loading bioreactor for mechanical stimulation of engineered cartilage.
A mechanical-conditioning bioreactor has been developed to provide bi-axial loading to three-dimensional (3D) tissue constructs within a highly controlled environment. The computer-controlled bioreactor is capable of applying axial compressive and shear deformations, individually or simultaneously at various regimes of strain and frequency. The reliability and reproducibility of the system were...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2013
ISSN: 1940-087X
DOI: 10.3791/50387