Design, Development and in vitro Evaluation of Hydrogels Prepared by Free Radical Polymerization of Acrylic Acid (AAc) Containing a Model Antidiabetic Drug

Abstract: Introduction: The controlled release of medicaments in the management diabetes is desirable to have a better therapeutic activity drug. Objectives: In present study hydrogels were prepared as drug delivery system taking Rosiglitazone model Materials and Methods: Hydrogels created using Free Radical Polymerization approach, with crosslinker N, N′-Methylene bisacrylamide serving binding agent for polymerization. To create polymeric network, ammonium persulphate has been used polymerization inducer AAc poly (acrylic acid) existence polyvinyl alcohol (PVP). A maximum fifteen formulations various concentrations polymers crosslinking agents test swelling, diffusion coefficients, ESR, vitro properties drugs tested. FT-IR DSC techniques determine drug's compatibility polymers. XRD studies carried out understand nature contained within hydrogel formulation. morphologies surface determined SEM. Results Discussion: greater swelling was observed basic pH range marginal acidic according studies. ESR affirmed that indeed factor gels. results revealed coefficient risen result reduction cross-linker concentration increase acrylic acid solution. data increased acid, which resulted However, when PVP increased, it discovered decreased. Conclusion: AAc-PVP based found be promising treatment Rosiglitazone, findings this study. Keywords: Hydrogels, Acrylic Polymerization, Antidiabetic Drug.