Design and synthesis of novel indole-quinoxaline hybrids to target phosphodiesterase 4 (PDE4)
نویسندگان
چکیده
منابع مشابه
Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies
To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...
متن کاملNovel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies
To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of Schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-Benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to Knoevenage...
متن کاملnovel thiazolidinone-azole hybrids: design, synthesis and antimycobacterial activity studies
to develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to knoevenage...
متن کاملDesign, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids.
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds exhibited moderate to satisfactory activity. F...
متن کاملDesign, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids.
By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2-21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiveness on the four tested cell lines. The anticancer screening results of the tested compounds provi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arabian Journal of Chemistry
سال: 2019
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2015.08.009