Design and Synthesis of 3-Substituted Indolin-2-one Derivatives with Methyl (E)-2-(3-Methoxy)acrylate Moiety
نویسندگان
چکیده
منابع مشابه
Synthesis and biological evaluation of 3-substituted-indolin-2-one derivatives containing chloropyrrole moieties.
Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethyl-amino)ethylcarbamoyl group as a substituent at the C-4' position of the pyrrole enhanced the antitumor activities notably. IC50 values as low as ...
متن کامل3-[(E)-Benzylidene]indolin-2-one
In the title indolin-2-one derivative, C(15)H(11)NO, the phenyl ring and the oxoindoline fused-ring system (r.m.s. deviation = 0.011 Å) are aligned at 48.52 (6)°. In the crystal, inversion-related mol-ecules form an N-H⋯O hydrogen-bonded dimer via an eight-membered {⋯HNCO}(2) synthon. The dimeric aggregates are linked into a three-dimensional architecture via C-H⋯O and π-π inter-actions between...
متن کامل(E)-3-(1-Phenylethylidene)indolin-2-one
In the title mol-ecule, C(16)H(13)NO, the indoline-2-one ring system is nearly planar [maximum atomic deviation = 0.082 (2) Å] and is oriented at a dihedral angle of 66.60 (12)° with respect to the phenyl ring. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into supra-molecular dimers.
متن کامل(E)-3-(2,6-Dichlorobenzylidene)indolin-2-one
There are two independent mol-ecules in the asymmetric unit of the title compound, C(15)H(9)Cl(2)NO. The dihedral angles between the oxindolyl and dichloro-phenyl rings are essentially identical for the two independent mol-ecules [63.4 (1) and 63.2 (1)°]. Dimers linked by amide-carbonyl N-H⋯O hydrogen bonds are formed from each symmetry-independent mol-ecule and the respective symmetry equivale...
متن کامل(Z)-3-[(E)-3-Phenylallylidene]indolin-2-one
The title compound, C(17)H(13)NO, synthesized to be tested for neuroprotective activities, consists of an indoline and a phenyl-allyl-idene unit with a dihedral angle of 9.0 (1)° between the two ring systems. There are two independent mol-ecules in the asymmetric unit which are connected into a dimer by inter-molecular N-H⋯O hydrogen bonds.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Asian Journal of Chemistry
سال: 2015
ISSN: 0970-7077,0975-427X
DOI: 10.14233/ajchem.2015.18286