Design and structure-activity relationships anticandidosic of diazaheteroaryl functionalized by Michaël acceptors

The management of candidiasis, once effective, is becoming more and difficult with the increase resistance various Candida species to classical antifungals. It in this context that we reported our previous works pharmacochemical development new diazaheteroaryls derivatives functionalized a Michael acceptor such as arylpropenone, arylacrylonitrile arylcyanopropenone. These benzimidazolyl-arylpropenone or benzimidazolyl-arylacrylonitriles benzimidazolyl-arylcyanopropenone imidazopyridinyl-arylpropenones structure were obtained by chemical synthesis then characterized usual spectroscopic methods (NMR MS). anticandidosic activities these expressed Minimum Inhibitory Quantity (MIQ) determined vitro on clinical strain albicans, following bioautography technique. results show have remarkable IMQ ranging from 10 0.16 µg. Moreover, performance different related nature structural variations undertaken benzene homocycle. This paper, which decade research team, will address design, overall serial structure-anticandidosic activity studies diaza-heteroaryls order propose compounds can be developed drug candidates.