Design and Investigation of Alginate Coated Solid Lipid Nanoparticles for Oral Insulin Delivery
نویسندگان
چکیده
منابع مشابه
Oral insulin delivery by means of solid lipid nanoparticles
The aim of this work was to produce and characterize cetyl palmitate-based solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration. SLN were prepared by a modified solvent emulsification-evaporation method based on a w/o/w double emulsion. The particle size, zeta potential and association efficiency of unloaded and in...
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Recently, solid lipid nanoparticles (SLNs) have attracted increasing attention owing to their potential as an oral delivery system, promoting intestinal absorption in the lymphatic circulation which plays a role in disseminating metastatic cancer cells and infectious agents throughout the body. SLN features can be exploited for the oral delivery of theranostics. Therefore, the aim of this work ...
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In recent years, encapsulation of drugs and antigens in hydrogels, specifically in calcium alginate particles, is an interesting and practical technique that was developed widespread. It is well known that alginate solution, under proper conditions, can form suitable nanoparticles as a promising carrier system, for vaccine delivery. The aim of this study was to synthesis alginate nanoparticles ...
متن کاملCrystallographic investigation of cetylpalmitate solid lipid nanoparticles.
Solid lipid nanoparticles (SLN) as alternative intravenous colloidal drug carriers were produced by high pressure homogenisation of the melted lipid cetylpalmitate. The crystallographic properties of the used cetylpalmitate SLN were characterised by small angle X-ray scattering (SAXS) and X-ray diffraction (XRD). It was found that the SLN are available exclusively in a crystalline form. Differe...
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In spite of the prevalence of subcutaneous injections for insulin administration, there are several concerns associated with this mode of administration including injection anxiety, pain, cost, infection, and as a result an overall decrease in patient compliance (Khafagy 2007). This has prompted researchers to search for alternative delivery methods including transdermal, nasal, pulmonary, rect...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Education and Research
سال: 2021
ISSN: 0019-5464
DOI: 10.5530/ijper.55.2.76