DESIGN AND EVALUATION OF LIQUISOLID COMPACTS OF NEBIVOLOL HYDROCHLORIDE

Objective: The aim of this study was to investigate the potential a liquisolid system improve dissolution rate and bioavailability nebivolol hydrochloride. Methods: Solubility determined in different nonvolatile solvents finalize best vehicle having maximum solubility. compacts were prepared using Fujicalin as carrier material, Aerosil 200 coating Polyethylene glycol 400 liquid vehicle, Croscarmellose sodium super disintegrating agent. 23 full factorial design used optimize formulation which drug concentration, PVP K 30, Excipient ratio (R), containing solvent level selected independent variables by expert software. eight compact formulations prepared. Nebivolol evaluated for content, tablet hardness, Friability, disintegration, dissolution. An vivo carried out male Wistar rats. Results: solubility hydrochloride polyethylene found be greater than other solvents. formulated successfully Fujicalin, 200, 400. In vitro evaluation parameters within prescribed limits. It that optimized showed higher marketed tablet, with 88.33±0.94 % release 120 min more 75 30 LS-3N, is optimized. LS-3N follow Peppas model exhibited first-order release. Conclusion: can promising alternative water-insoluble improved bioavailability.