Design and Development of Halogenated Chalcone Derivatives as Potential Anticancer Agents
نویسندگان
چکیده
منابع مشابه
Design and Development of Halogenated Chalcone Derivatives as Potential Anticancer Agents
Purpose: To design and develop halogenated chalcone derivatives and evaluate them as anticancer agents using different cancer cell lines. Methods: Based on in silico design and docking on known target, crystal structure of the complex of interleukin-1beta converting enzyme (ICE) with a peptide based inhibitor, (3S )-N-Methanesulfonyl-3({1-[N-(2-naphtoyl)-l-valyl]-l-prolyl}amino)-4-oxobutanamide...
متن کاملSynthesis and In-vitro Evaluation of Copolyester- Chalcone Derivatives as Potential Anticancer Agents
A new series of copolyester chalcone derivatives were synthesised from 1, 3-bis (4-hydroxy-3methoxyphenyl) propenone (BHMPP) and 1(3, 5-dihydroxyphenyl)-3-(4-methoxyphenyl) propenone (DHPMPP) with adipoyl, suberoyl, azeloyl and sebacoyl chlorides by phase transfer catalysed polycondensation method. The microstructure of the repeating unit was confirmed by IR, 1 H and 13 C NMR. These copolyester...
متن کاملSynthesis and Evaluation of Bakuchiol Derivatives as Potential Anticancer Agents.
A series of bakuchiol derivatives were synthesized and evaluated for their anti-proliferative and the inhibitory activities on SMMC7721 cell line migration using PX-478 as a positive control. The results showed (S,E)-4-(7-methoxy-3,7-dimethyl-3-vinyloct-1-en-1-yl)phenol (10) to have the best activity among the tested compounds, which included PX-478. In addition, compound 10 showed greater inhi...
متن کاملSynthesis and anticancer activity assay of novel chalcone sulfonamide derivatives
Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...
متن کاملSynthesis and anticancer activity assay of novel chalcone sulfonamide derivatives
Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2014
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v13i1.11