Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection
نویسندگان
چکیده
منابع مشابه
Global metabolic responses of mice to Trypanosoma brucei brucei infection.
Human African trypanosomiasis (HAT) is transmitted by tsetse flies and, if untreated, is fatal. Treatment depends on infection stage, and early diagnosis is crucial for effective disease management. The systemic host biochemical changes induced by HAT that enable biomarker discovery or relate to therapeutic outcome are largely unknown. We have characterized the multivariate temporal responses o...
متن کاملSusceptibility of Grammomys surdaster thicket rats to Trypanosoma brucei gambiense infection.
Human African Trypanosomiasis is caused by Trypanosoma brucei gambiense and T. b. rhodesiense. Historically, a treatment relapse rate of about 5% is observed in patients treated with melarsoprol, an arsenical derivative used for treatment of both gambiense and rhodesiense second stage sleeping sickness. More recently, relapse rates up to 30% are noted in gambiense sleeping sickness foci in Ango...
متن کاملA comparative study on the susceptibility of male and female albino mice to Trypanosoma brucei brucei.
BACKGROUND & OBJECTIVES Trypanosomiasis has remained a major set-back in the development of livestock farming in tropical Africa. Thus the need for ascertaining the trypanotolerant levels of domestic animal breeds and possible improvement on them cannot be over-emphasised. METHODS Level of trypanotolerance in animals was compared between sexes using albino mice infected with a Nigerian strain...
متن کاملTrypanosoma brucei brucei
Protein synthesis in Trypanosoma brucei brucei was rapidly inhibited during polyamine depletion by DL-adifluoromethylornithine (DFMO) in vitro and in vivo. [3H]Leucine incorporation was depressed 30-40 % by 24 h and 80-90 % by 48 h of DFMO treatment. Concomitantly there was an apparent decrease in the synthesis of the variant-specific glycoprotein (VSG) in DFMO-treated trypanosomes, as measured...
متن کاملLow-dose intradermal infection with trypanosoma congolense leads to expansion of regulatory T cells and enhanced susceptibility to reinfection.
BALB/c mice are highly susceptible to experimental intraperitoneal Trypanosoma congolense infection. However, a recent report showed that these mice are relatively resistant to primary intradermal low-dose infection. Paradoxically, repeated low-dose intradermal infections predispose mice to enhanced susceptibility to an otherwise noninfectious dose challenge. Here, we explored the mechanisms re...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-89053-2