Dermal application of JP-8 jet fuel induces immune suppression
نویسندگان
چکیده
منابع مشابه
Dermal exposure to jet fuel (JP-8) in US Air Force personnel.
Limited research has been conducted on dermal exposure and risk assessment, owing to the lack of reliable measurement techniques and data for quantitative risk assessment. We investigated the magnitude of dermal exposure to jet propulsion fuel 8 (JP-8), using naphthalene as a surrogate, on the US Air Force fuel-cell maintenance workers. Dermal exposure of 124 workers routinely working with JP-8...
متن کاملUrinary biomarkers of exposure to jet fuel (JP-8).
Benzene, naphthalene, and 1- and 2-naphthol were measured in urine samples obtained from 322 U.S. Air Force personnel categorized a priori as likely to have low, moderate, or high exposure to jet fuel [jet propulsion fuel-8 (JP-8)]. In postexposure samples, levels of these analytes in the high-exposure group were 3- to 29-fold greater than in the low-exposure group and 2- to 12-fold greater tha...
متن کاملDermal absorption and distribution of topically dosed jet fuels jet-A, JP-8, and JP-8(100).
Dermal exposure to jet fuels has received increased attention with the recent release of newer fuels with novel performance additives. The purpose of these studies was to assess the percutaneous absorption and cutaneous disposition of topically applied (25 microl/5 cm(2)) neat Jet-A, JP-8, and JP-8(100) jet fuels by monitoring the absorptive flux of the marker components 14C naphthalene and (3)...
متن کاملDermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers
Jet propulsion fuel 8 (JP-8) is the major jet fuel used worldwide and has been recognized as a major source of chemical exposure, both inhalation and dermal, for fuel-cell maintenance workers. We investigated the contributions of dermal and inhalation exposure to JP-8 to the total body dose of U.S. Air Force fuel-cell maintenance workers using naphthalene as a surrogate for JP-8 exposure. Derma...
متن کاملBiodegradation of Jet Fuel (jp-8) in the Presence of Vegetation
The environmental impact of spills of JP-8, a kerosene-based jet fuel, has been studied very little. For the more volatile JP-4, earlier studies showed that biodegradation was less important than evaporation but for JP-8, evaporative loss from soil is very slow. Disappearance of JP-8 from watered mesocosms was monitored over several months. In two, 10-cm wide x 35-cm deep x 180-cm long channels...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1999
ISSN: 1096-0929
DOI: 10.1093/toxsci/52.1.61