Derivatives of cephalosporin C formed with certain heterocyclic tertiary bases. The cephalosporin CA family
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منابع مشابه
Cephalosporin podand derivatives.
work in the synthesis of podand molecules6), the present paper describes the preparation of certain podand-type trimers of cephalosporin antibiotics (Scheme 1 ). As the central block of the target trimers the tricarboxylic acid 3 was employed, which was obtained by the alkylation of phloroglucinol (1) with methyl bromoacetate and subsequent alkaline hydrolysis. The tert-butyl esters of 7-aminoc...
متن کاملBiosynthesis of cephalosporin C.
The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cy...
متن کاملPreparation of 7-epi-cephalosporin derivatives.
position 6,1-4) the preparation of 7-epi-aminocephalosporanic 'acid (7a-ACA) has thus far not been reported. Some 7-epi-cephalosporins have been prepared by base-catalyzed epimerization of cephalosporin sulfoxidesu or acidcatalyzed ring expansion of 6-epi-penicillins.e) Both procedures, however, are not convenient for the preparation of 7-epi-cephalosporin derivatives. We wish to report the direct
متن کاملThe X - Ray Analysis of Cephalosporin C
Bulow, C. & Seidel, F. (1924). Liebigs Ann. 439, 48. Cavallini, D., Frontali, N. & Toschi, G. (1949). Nature, Lond., 163, 568. De Ropp, R. S., Van Meter, J. C., De Renzo, E. C., McKerns, K. W., Pidacks, C., Bell, P. H., Ullman, E. F., Safir, S. R., Fanshawe, W. J. & Davis, S. B. (1958). J. Amer. chem. Soc. 80, 1004. Ellington, E. V., Hassall, C. H. & Plimmer, J. R. (1958). Chem. & Ind. p. 329. ...
متن کاملBiological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics.
Three new cephalosporin antibiotics, prepared by substitution of heterocyclic groups on 7-aminocephalosporanic acid, possess certain desirable chemical or biological properties. All three compounds are active in vitro against a variety of gram-positive and gram-negative bacteria. Minimal inhibitory concentrations (MIC) of these bactericidal antibiotics were not significantly affected by changes...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1961
ISSN: 0306-3283
DOI: 10.1042/bj0790403