Depletion of Esterase‐Harboring Bacteria Increases Antihypertensive Efficacy of ACE Inhibitor Quinapril
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چکیده
منابع مشابه
L Effect of ACE Inhibitor , Quinapril , on Neointimal Formation after Balloon Injury
Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells in vitro. Consistent with this, Ang II enhances neointimal proliferation in vivo after vascular injury, while angiotensin converting enzyme (ACE) inhibitors attenuate this process. Since tissue ACE plays a key role in the control of local Ang II production, we examined whether vascular injury resulted in an increase in vasc...
متن کاملQuinapril, an ACE inhibitor, reduces markers of oxidative stress in the metabolic syndrome.
OBJECTIVE Patients with the metabolic syndrome often have abnormal levels of proinflammatory and pro-oxidative mechanisms within their vasculature. We sought to determine whether the ACE inhibitor quinapril regulates markers of oxidative stress in the metabolic syndrome. RESEARCH DESIGN AND METHODS Forty patients with the metabolic syndrome were randomized in a double-blind manner to either t...
متن کاملChronic ACE inhibition by quinapril modulates central vasopressinergic system.
OBJECTIVE The role of the brain as a target for angiotensin converting enzyme (ACE) inhibitors in the treatment of heart failure and hypertension is unclear. To test the hypothesis that ACE inhibitors may modulate other central neuropeptide systems such as the central vasopressin system, we studied the effects of chronic treatment with the ACE inhibitor, quinapril, on ACE activity and on centra...
متن کاملA retrospective clinical study of the safety and efficacy of AFA mixture, an herbal antihypertensive product
Background & Aim: Hypertension is an incurable disease which has become a common major risk factor for many cardiovascular diseases worldwide. Besides increasing the risk of heart diseases and stroke, hypertension can also lead to other health conditions such as renal disease and diabetes. The prolong use of orthodox antihypertensive are usually associated with many side effect...
متن کاملVascular effects of quinapril completely depend on ACE insertion/deletion polymorphism.
INTRODUCTION The angiotensin-converting enzyme (ACE) DD-genotype is associated with increased plasma and myocardial ACE-activity. The influence of the ACE insertion/deletion (I/D) polymorphism on the effects of ACE-inhibition on vascular responses has not been previously described. MATERIALS AND METHODS In the randomised, double-blind QUinapril On Vascular ACE and Determinants of Ischemia Stu...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.02954