Depigmented Allergoids Reveal New Epitopes with Capacity to Induce IgG Blocking Antibodies
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چکیده
منابع مشابه
Depigmented Allergoids Reveal New Epitopes with Capacity to Induce IgG Blocking Antibodies
BACKGROUND The synthesis of allergen-specific blocking IgGs that interact with IgE after allergen immunotherapy (SIT) has been related to clinical efficacy. The objectives were to investigate the epitope specificity of IgG-antibodies induced by depigmented-polymerized (Dpg-Pol) allergoids and unmodified allergen extracts, and examine IgE-blocking activity of induced IgG-antibodies. METHODS Ra...
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were either unresponsive or showed elevated mRNA levels of the Th1-promoting chemokines CXCL10 and CXCL11. Conclusions: This study supported by grant SFB-F1802 of the Austrian Science Fund shows for the first time that the allergen uptake is specific and similar in DCs from allergic and healthy individuals. More important, the ensuing signal cascade that is triggered by the allergen differs bet...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2013
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2013/284615