Dentistry and Molecular Biology: A Promising Field for Tooth Agenesis Management
نویسندگان
چکیده
منابع مشابه
Dentistry and molecular biology: a promising field for tooth agenesis management.
Tooth agenesis is the failure of tooth bud development, causing definitive absence of the tooth. It is the most common dental anomaly, affecting up to one-quarter of the general population. The main cause is related to abnormal function of specific genes which play key roles during odontogenesis, particularly MSX1 and PAX9. MSX1 is a transcription factor highly expressed in the mesenchyme of...
متن کاملOperative Dentistry and Biomaterials for Tooth Regenration
Tissue-engineered biomaterials have existed approximately 40 years as simple biomimetic structures. Replacement of human tissue with new tissue can be accomplished by generating replacements outside of the body or in situ in the body. In each case, the key elements are described as the tissue engineering triad of scaffolds, cells, and signals. Scaffolds can be produced synthetically or derived ...
متن کاملTooth Agenesis
Tooth agenesis denotes a condition where teeth are missing due to a developmental failure. According to severity, this malformation can be subdivided into hypodontia, oligodontia and anodontia. With a frequency of 20–30%, tooth agenesis is the most prevalent dental dysplasia, but not all teeth are equally affected. Familial occurrence and concordance in twins indicate potential genetic causes. ...
متن کاملGenetic basis of dental agenesis - molecular genetics patterning clinical dentistry
Tooth agenesis is one of the most common congenital malformations in humans. Hypodontia can either occur as an isolated condition (non-syndromic hypodontia) or can be associated with a syndrome (syndromic hypodontia), highlighting the heterogeneity of the condition. Though much progress has been made to identify the developmental basis of tooth formation, knowledge of the etiological basis of i...
متن کاملGenetics of tooth agenesis: how to move the field forward
Tooth agenesis is the congenital lack of one or more of the deciduous or permanent teeth. Oligodontia is the agenesis of six or more permanent teeth (excluding third molars), whereas absence of less than six teeth is referred to as hypodontia. Anodontia refers to the absence of all deciduous and permanent teeth. Tooth agenesis occurs more frequently among a few specific teeth (lateral incisors,...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 2012
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.226.243