Deneysel hipertiroidide fiziksel ve vital bulguların ve karnozinin etkisinin değerlendirilmesi

Purpose: This study aims to investigate the effects of experimental hyperthyroidism and carnosine which is known have antioxidant properties on physical vital findings in rats, determine relationship between these parameters free T3 (FT3) levels.
 Materials Methods: Rats were analyzed 7 groups (each containing 12 animals); control (CONT), hyperthyroidism-1 (T:10-day L-thyroxine (L-T4) administration), hyperthyroidism-2 (T-T: 20-day L-T4 Carnosine (10 day Hyperthyroidism-1 + (T-C), Hyperthyroidism-2 (T-TC), (C-T). In order create a model, doses 300 µg/kg rat weight/day weight/ intraperitoneally (ip) administered rats. 
 Results: After 10 20 days thyroxine administration, FT3 levels (T:3.640.51pg/mL, T-T: 4.060.91pg/mL) body temperature (T:37.10.3oC, 37.60.3oC), significantly increased while weight decreased (T:240.722.0g, T-T:263.028.7g). administration only prevented increase levels, but had no effect other parameters. Conclusion: The observed with consistent findings, did not reflect expected hyperthyroid condition.