Denervation impairs bone regeneration during distraction osteogenesis in rabbit tibia lengthening
نویسندگان
چکیده
منابع مشابه
Denervation impairs bone regeneration during distraction osteogenesis in rabbit tibia lengthening
BACKGROUND AND PURPOSES The nervous system plays an important role in bone metabolism. However, the effect of denervation on bone formation during distraction osteogenesis (DO) remains unclear. We studied neural influence on bone regeneration during DO in a rabbit model. METHODS 24 New Zealand male white rabbits underwent left tibial osteodistraction. Before distraction, the animals were rand...
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Bone is amongst the very few tissues in the human body that possess intrinsic capacity to heal spontaneously following injury. However, beyond a certain critical size defect, bone cannot heal by itself and outside intervention is required. Numerous techniques are available for the management of these defects, including the gold standard autogenous bone grafts, allografts, bone graft substitutes...
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The treatment of bone defects is challenging and controversial. As a new technology, periosteal distraction osteogenesis (PDO) uses the osteogenicity of periosteum, which creates an artificial space between the bone surface and periosteum to generate new bone by gradually expanding the periosteum with no need for corticotomy. Using the newly formed bone of PDO to treat bone defects is effective...
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Introduction: Distraction osteogenesis is widely used in orthopaedic reconstruction for congenital disease, traumatic bony defects, and tumoral conditions, but this procedure has a disadvantage of prolonged healing time. The administration of the nitrogen containing bisphosphonate (NBP) by intravenous injection increased bone during distraction osteogenesis in animal experimentations (1). Bisph...
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We investigated the effect of locally administered bisphosphonate on distraction osteogenesis in a rabbit model and evaluated its systemic effect. An osteotomy on the right tibia followed by distraction for four weeks was performed on 47 immature rabbits. They were divided into seven equal groups, with each group receiving a different treatment regime. Saline and three types of dosage of alendr...
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ژورنال
عنوان ژورنال: Acta Orthopaedica
سال: 2012
ISSN: 1745-3674,1745-3682
DOI: 10.3109/17453674.2012.702389