Dendritic spine dysgenesis in Rett syndrome
نویسندگان
چکیده
منابع مشابه
Dendritic spine dysgenesis in Rett syndrome
Spines are small cytoplasmic extensions of dendrites that form the postsynaptic compartment of the majority of excitatory synapses in the mammalian brain. Alterations in the numerical density, size, and shape of dendritic spines have been correlated with neuronal dysfunction in several neurological and neurodevelopmental disorders associated with intellectual disability, including Rett syndrome...
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Hyperreflexia and spasticity are chronic complications in spinal cord injury (SCI), with limited options for safe and effective treatment. A central mechanism in spasticity is hyperexcitability of the spinal stretch reflex, which presents symptomatically as a velocity-dependent increase in tonic stretch reflexes and exaggerated tendon jerks. In this study we tested the hypothesis that dendritic...
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Neuropathic pain is a major complication of spinal cord injury, and despite aggressive efforts, this type of pain is refractory to available clinical treatment. Our previous work has demonstrated a structure-function link between dendritic spine dysgenesis on nociceptive sensory neurons in the intermediate zone, laminae IV/V, and chronic pain in central nervous system and peripheral nervous sys...
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1 SPINAL CORD INJURY 2 3 Abbreviated title: Dendritic Spine Dysgenesis in Hyperreflexia after SCI 4 5 Samira P. Bandaru, Shujun Liu, Stephen G. Waxman, and Andrew M. Tan 6 7 Department of Neurology and Center for Neuroscience and Regeneration Research, 8 Yale University School of Medicine, New Haven, CT 06510, and Rehabilitation 9 Research Center, Veterans Affairs Connecticut Healthcare System,...
متن کامل[Rett syndrome].
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ژورنال
عنوان ژورنال: Frontiers in Neuroanatomy
سال: 2014
ISSN: 1662-5129
DOI: 10.3389/fnana.2014.00097