Delphinidin suppresses breast carcinogenesis through the HOTAIR /micro RNA ‐34a axis
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چکیده
منابع مشابه
Long non-coding RNA HOTAIR in carcinogenesis and metastasis.
Long non-coding RNAs (lncRNAs) have gained massive attention in recent years as a potentially new and crucial layer of gene regulation. LncRNAs are prevalently transcribed in the genome, but their roles in gene regulation and disease development are largely unknown. HOX antisense intergenic RNA (HOTAIR), a lncRNA located in the HOXC locus, has been shown to repress HOXD gene expression and prom...
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HOTAIR (HOX transcript antisense RNA) plays a critical role in chromatin dynamics through the interaction with histone modifiers resulting in transcriptional gene silencing. The promoter of the HOTAIR gene contains multiple estrogen response elements (EREs) and is transcriptionally activated by estradiol in estrogen receptor-positive breast cancer cells. HOTAIR competes with BRCA1, a critical p...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2019
ISSN: 1347-9032,1349-7006
DOI: 10.1111/cas.14133