Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression
نویسندگان
چکیده
منابع مشابه
Oxidative stress and disuse muscle atrophy.
Skeletal muscle inactivity is associated with a loss of muscle protein and reduced force-generating capacity. This disuse-induced muscle atrophy results from both increased proteolysis and decreased protein synthesis. Investigations of the cell signaling pathways that regulate disuse muscle atrophy have increased our understanding of this complex process. Emerging evidence implicates oxidative ...
متن کاملMuscle Deconditioning and Disuse Atrophy
Lack of physical activity can cause a muscle to atrophy. Muscle deconditioning may become apparent within days to weeks of decreased physical activity. For example, we have all known individuals who were physically fit during their high school days and then became less active over time. The cessation of regular activity causes the muscles to decrease in size, but contrary to what some people sa...
متن کاملRedox homeostasis, oxidative stress and disuse muscle atrophy.
A pivotal role has been ascribed to oxidative stress in determining the imbalance between protein synthesis and degradation leading to muscle atrophy in many pathological conditions and in disuse. However, a large variability in disuse-induced alteration of redox homeostasis through muscles, models and species emerges from the literature. Whereas the causal role of oxidative stress appears well...
متن کاملMechanisms of disuse muscle atrophy: role of oxidative stress.
Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength. Advances in cell biology have progressed our understanding of those factors that contribute to muscle atrophy. To this end, abundant evidence implicates oxidative stress as a potential regulator of proteolytic pathways leading to muscle atrophy during periods of prolonged disuse. This review will addr...
متن کاملExpression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophy.
Disuse atrophy of skeletal muscle leads to an upregulation of genes encoding sarcoplasmic reticulum (SR) calcium-handling proteins. Because many of the proteins that are induced with endoplasmic reticulum (ER) stress are ER calcium-handling proteins, we sought to determine whether soleus muscle atrophy was associated with a prototypical ER stress response. Seven days of rat hindlimb unloading d...
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ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 2016
ISSN: 0916-8451,1347-6947
DOI: 10.1080/09168451.2016.1184560