Delivery of stromal cell-derived factor 1α for in situ tissue regeneration
نویسندگان
چکیده
منابع مشابه
Delivery of stromal cell-derived factor 1α for in situ tissue regeneration
In situ tissue regeneration approach aims to exploit the body's own biological resources and reparative capability and recruit host cells by utilizing cell-instructive biomaterials. In order to immobilize and release bioactive factors in biomaterials, it is important to engineer the load effectiveness, release kinetics and cell recruiting capabilities of bioactive molecules by using suitable bo...
متن کاملPretreatment of Mesenchymal Stem Cells and Stromal-derived Factor-1α Delivery from Chitosan-based Injectable Hydrogels for Better Cell Guidance and Retention
Clinical applications of mesenchymal stem cells (MSCs) rely on their capacity to home and engraft in the appropriate target tissues for a long time. Homing and engraftment capacity of these stem cells depend on the expression of Chemokines and their receptors. Ex vivo expanded MSCs exhibit homing potential when grafted to injury tissue but their homing efficiency has been observed very poor bec...
متن کاملpretreatment of mesenchymal stem cells and stromal-derived factor-1α delivery from chitosan-based injectable hydrogels for better cell guidance and retention
clinical applications of mesenchymal stem cells (mscs) rely on their capacity to home and engraft in the appropriate target tissues for a long time. homing and engraftment capacity of these stem cells depend on the expression of chemokines and their receptors. ex vivo expanded mscs exhibit homing potential when grafted to injury tissue but their homing efficiency has been observed very poor bec...
متن کاملCollagen modules for in situ delivery of mesenchymal stromal cell-derived endothelial cells for improved angiogenesis.
Modular tissue engineering is a strategy to create scalable, self-assembling, three-dimensional (3D) tissue constructs. This strategy was used to deliver endothelial-like cells derived from bone marrow mesenchymal stromal cells (EL-MSCs) to locally induce vascularization. First, tissue engineered modules were formed, comprising EL-MSCs and collagen-based cylinders. Seven days of module culture ...
متن کاملStromal Cell-Derived Factor 1α Induces Accumulation of Intraveneously Administered Marrow-Derived Stromal Cells in the Partially Obstructed Rat Bladder.
OBJECTIVES We investigated the time course of the stromal cell-derived factor 1α (SDF1α) expression and behavior of intravenously administered bone marrow-derived stromal (BMS) cells in the urinary bladder of partial bladder outlet obstruction (PBOO) rats. METHODS Study 1: Recombinant SDF1α or saline was directly injected into the bladder wall of female rats followed by intravenous administra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Engineering
سال: 2017
ISSN: 1754-1611
DOI: 10.1186/s13036-017-0058-3