Deletions in CWH43 cause idiopathic normal pressure hydrocephalus
نویسندگان
چکیده
منابع مشابه
Idiopathic Normal Pressure Hydrocephalus
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurodegenerative disease commonly characterized by a triad of dementia, gait, and urinary disturbance. Advancements in diagnosis and treatment have aided in properly identifying and improving symptoms in patients. However, a large proportion of iNPH patients remain either undiagnosed or misdiagnosed. Using PubMed searc...
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Q rimary care providers (PCPs) often see elderly patients in their practice with symptoms of dementia, usually because of irreversible conditions. Normal pressure hydrocephalus (NPH) is an often unrecognized cause of dementia symptoms, and can be reversible with appropriate diagnosis and treatment, specifically ventriculoperitoneal (VP) shunting. It has been estimated that 375,000 Americans mis...
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Background: We have previously seen that idiopathic normal pressure hydrocephalus (iNPH) patients havingelevated intracranial pressure (ICP) pulse amplitude consistently respond to shunt surgery. In this study weexplored how the cerebrospinal fluid pressure (CSFP) pulse amplitude determined during lumbar infusion testing,correlates with ICP pulse amplitude determined during over-nig...
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The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so ...
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Normal pressure hydrocephalus (NPH) has posed a challenge to neurologists for 5 decades. Difficulties in understanding its pathophysiology have hindered efforts to diagnose it and to develop a better approach to selecting patients for shunt surgery. We know that many patients with NPH have CSF absorption difficulty as measured by resistance to CSF outflow (Rout). The problem is that many with n...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2021
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.202013249