Deletion of Chromosome 9p21 Noncoding Cardiovascular Risk Interval in Mice Alters Smad2 Signaling and Promotes Vascular Aneurysm
نویسندگان
چکیده
منابع مشابه
Deletion of chromosome 9p21 noncoding cardiovascular risk interval in mice alters Smad2 signaling and promotes vascular aneurysm.
BACKGROUND Vascular aneurysm is an abnormal local dilatation of an artery that can lead to vessel rupture and sudden death. The only treatment involves surgical or endovascular repair or exclusion. There is currently no approved medical therapy for this condition. Recent data established a strong association between genetic variants in the 9p21 chromosomal region in humans and the presence of c...
متن کاملRegulatory elements in noncoding DNA in the chromosome 9p21 locus.
Study Hypothesis A novel locus on chromosome 9p21 has been identified in numerous genome-wide association studies as the most highly associated with coronary artery disease (CAD) and myocardial infarction. Understanding the mechanism by which the locus influences disease has been a challenge because the locus lies entirely within noncoding DNA—in a so-called “gene desert” at a long distance fro...
متن کاملMedical Policy Genotyping for 9p21 Single Nucleotide Polymorphisms to Predict Risk of Cardiovascular Disease or Aneurysm
Related Policies Measurement of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in the Assessment of Cardiovascular Risk, #558 Novel Lipid Risk Factors in Risk Assessment and Management of Cardiovascular Disease, #283 Gene Expression Testing to Predict Coronary Artery Disease, #349 Genetic Testing for Lipoprotein-a Variants as a Decision Aid for Aspirin Treatment, #339 KIF6 Genotypi...
متن کاملGenotyping for 9p21 Single Nucleotide Polymorphisms to Predict Risk of Cardiovascular Disease or Aneurysm
Related Policies Measurement of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in the Assessment of Cardiovascular Risk, #558 Novel Lipid Risk Factors in Risk Assessment and Management of Cardiovascular Disease, #283 Gene Expression Testing to Predict Coronary Artery Disease, #349 Genetic Testing for Lipoprotein-a Variants as a Decision Aid for Aspirin Treatment, #339 KIF6 Genotypi...
متن کاملGenotyping for 9p21 Single Nucleotide Polymorphisms to Predict Risk of Cardiovascular Disease or Aneurysm
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2014
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.114.000696