Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression
نویسندگان
چکیده
منابع مشابه
Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression.
CONTEXT Alternative and over-the-counter medicines have become increasingly popular choices for many patients who prefer not to take traditional antidepressants. The adrenal androgen and neurosteroid dehydroepiandrosterone (DHEA) is available as over-the-counter hormonal therapy and previously has been reported to have antidepressant-like effects. OBJECTIVE To evaluate the efficacy of DHEA as...
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BACKGROUND The authors sought to examine whether levels of dehydroepiandrosterone are abnormal in depression. METHODS Three groups of subjects aged 20-64 were studied: 44 major depressives, 35 subjects with partially or completely remitted depression, matched as far as possible for age and drug treatment, and 41 normal control subjects. Dehydroepiandrosterone and cortisol in saliva were deter...
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The purpose of our study was to examine the neuroanatomical correlates of late-onset minor and major depression and to compare them with similar measures obtained from nondepressed controls. Our study groups were comprised of 18 patients with late-onset minor depression, 35 patients diagnosed with late-onset major depression, and 30 nondepressed controls. All subjects were scanned by using a 1....
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Although emotional dysfunction is an important aspect of major depressive disorder (MDD), it has rarely been studied in daily life. Peeters, Nicolson, Berkhof, Delespaul, and deVries (2003) observed a surprising mood-brightening effect when individuals with MDD reported greater reactivity to positive events. To better understand this phenomenon, we conducted a multimethod assessment of emotiona...
متن کاملDouble-blind treatment of major depression with dehydroepiandrosterone.
OBJECTIVE This study was designed to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans. METHOD Twenty-two patients with major depression, either medication-free or on stabilized antidepressant regimens, received either DHEA (maximum dose = 90 mg/day) or placebo for 6 weeks in a double-blind manner and were rated at baseline a...
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ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2005
ISSN: 0003-990X
DOI: 10.1001/archpsyc.62.2.154