Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model
نویسندگان
چکیده
منابع مشابه
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Epithelial-mesenchymal transition (EMT) enables epithelial cells to acquire motility and invasiveness that are characteristic of mesenchymal cells. It plays an important role in development and tumor cell metastasis. However, the mechanisms of EMT and their dysfunction in cancer cells are still not well understood. Here we report that Siva1 interacts with stathmin, a microtubule destabilizer. S...
متن کاملCystatin A suppresses tumor cell growth through inhibiting epithelial to mesenchymal transition in human lung cancer
Cystatin A (CSTA), belonging to type 1 cystatin super-family, is expressed primarily in epithelial and lymphoid tissues for protecting cells from proteolysis of cytoplasmic and cytoskeletal proteins by cathepsins B, H and L. CSTA acts as a tumor suppressor in esophageal cancer, however, its role in lung cancer has not yet been elucidated. Here we found that CSTA was down-regulated in all lung c...
متن کاملMetadherin knockdown suppresses bladder cancer cell invasion and metastasis by inhibiting the epithelial to mesenchymal transition
Metadherin is over-expressed in several cancers and it is has been considered as an important oncogene. Recent studies have shown that elevated expression of metadherin is associated with poor prognosis in patients with transitional cell carcinoma, however, the potential role of metadherin in transitional cell carcinoma remains unknown. In this study, Paraffin sections of clinical bladder sampl...
متن کاملCurcumin suppresses epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells by inhibiting cancer-associated fibroblasts.
Pancreatic cancer is one of the most lethal malignancies and the fourth leading cause of cancer-related deaths worldwide, because of its aggressive and highly metastatic ability even in its early stages. Cancer-associated fibroblasts (CAFs) have been reported to be vital to pancreatic cancer progression via regulating tumorigenesis and metastasis. Studies have shown that CAFs also mediate epith...
متن کاملMiR-195 suppresses the metastasis and epithelial–mesenchymal transition of hepatocellular carcinoma by inhibiting YAP
MiR-195, a novel cancer-related microRNA, was previously reported to play an important role in many malignancies. This study aimed to investigate the role of miR-195 mediated epithelial-mesenchymal transition (EMT) and the progression of hepatocellular carcinoma (HCC) as well as the underlying mechanisms. Our result demonstrated that miR-195 were significantly down regulated in HCC and its decr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncogene
سال: 2012
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2012.413