Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway
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چکیده
منابع مشابه
Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway
Angiogenesis plays a crucial role in the development of human hepatocellular carcinoma (HCC). In the present study, we found a natural compound, deguelin, has a profound anti-angiogenesis effect on HCC. Deguelin suppressed vascular endothelial growth factor (VEGF)-induced human umbilical vascular endothelial cells (HUVECs) proliferation, migration, invasion, and capillary-like tube formation in...
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Hepatocellular carcinoma (HCC) is a significant cause of cancer-related morbidity and mortality worldwide. Despite improvements in local therapies, including surgical resection, liver transplantation, and transarterial embolization, the prognosis remains poor for the majority of patients who develop recurrence or present with advanced disease. Systemic therapy with the tyrosine kinase inhibitor...
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The poor prognosis of hepatocellular carcinoma (HCC), one of the most devastating cancers worldwide, is due to frequent recurrence and metastasis. Among the metastatic factors in the tumor microenvironment, hepatocyte growth factor (HGF) has been well known to play critical roles in tumor progression, including HCC. Therefore, c-Met is now regarded as the most promising therapeutic target for t...
متن کاملHGF - MET and angiogenesis
1. Abstract 2. Significance of HGF-Met in molecular target therapy of cancer 3. NK4 as HGF-antagonist 4. Biological activity of NK4 as angiogenesis inhibitor 5. Experimental cancer treatment by gene expression of NK4 5.1. Inhibition of invasion-metastasis associated with Met inactivation by NK4 gene therapy 5.2. NK4 gene therapy using recombinant adenovirus for metastatic cancers 6. Conclusion ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.22077