Defining treatment thresholds for neonatal hypoglycaemia—how low is too low?

Is Inflation Too Low?

W hat is today’s big monetary policy issue? It is, surely, the extraordinary volatility of the financial markets and the wide quality spreads that opened up between riskier bonds and Treasury bonds following the Russian default in mid-August 1998. No one forecast these problems; the financial-market upset certainly was not a real, live policy issue back in the spring and early summer. We should...

Aiming too high or too low? Searching for the appropriate therapeutic thresholds in hypertension is not over yet.

Context Increased arterial blood pressure (BP) is an established and modifiable cardiovascular (CV) risk factor. Consequently, the decision on antihypertensive treatment has been in the focus of changing recommendations over the past decades, initially with higher accepted BP thresholds than those recommended by modern guidelines. However, recently published consensus statements have indicated ...

How low is too low? Cardiac risks with anemia

Despite the increasing availability of data supporting more restrictive transfusion practices, the risks and benefits of transfusing critically ill patients continue to evoke controversy. Past retrospective and observational studies suggested that liberal transfusion strategies were more beneficial in patients whose hematocrit levels fell below 30%. An expanding body of literature suggests that...

How novel is too novel? Stream community thresholds at exceptionally low levels of catchment urbanization.

Novel physical and chemical conditions of many modern ecosystems increasingly diverge from the environments known to have existed at any time in the history of Earth. The loss of natural land to urbanization is one of the most prevalent drivers of novel environments in freshwaters. However, current understanding of aquatic community response to urbanization is based heavily upon aggregate indic...

Is the recommended daily iron intake for women too low?