Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae
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چکیده
منابع مشابه
Defining targets for complement components C4b and C3b on the pathogenic neisseriae.
Complement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide on Neisseria meningitidis as an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization and killing. In this study we demonstrate that N...
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The complement fragments C3b and C4b are the main ligands for the membrane receptor CR1. We showed elsewhere that CR1 functions as an essential cofactor for the factor I-mediated enzymatic breakdown of membrane-bound C3b (*C3b) into C3c and * C3dg . One of the main findings of the present paper is that CR1 also promotes the degradation of bound C4b (*C4b) into C4c and *C4d. On a weight basis, t...
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The C5 convertase of the classical complement pathway is a complex enzyme consisting of three complement fragments, C4b, C2a, and C3b. Previous studies have elucidated functional roles of each subunit (4, 6, 7), but little is known about how the subunits associate with each other. In this investigation, we studied the nature of the classical C5 convertase that was assembled on sheep erythrocyte...
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Complement receptor type one (CR1) was isolated from detergent-solubilized human erythrocyte (E) membranes by modification of a previously described technique. The isolated CR, was labeled with 1251 and was shown to be bound by either C4bor CSb-coated sheep E (EAC14b or ECBb), but not by sheep E coated with either C3bi or C3d (EC3bi or EC3d). When analyzed by sodium dodecyl sulfate polyacrylami...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2008
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00613-07