منابع مشابه
Defining miRNA targets: balancing simplicity with complexity.
M icro RNAs (miRNAs) are small RNAs that play an important role in the negative regulation of gene expression by suppressing protein translation. Animal genomes contain an abundance of small genes that produce regulatory RNAs of ≈22 nucleotides in length. The Ambros laboratory identified the first miRNAs in 1993 while characterizing a genetic locus involved in the control of developmental timin...
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A n explosion of new techniques to explore DNA and protein biology during the last 2 decades has illuminated one of the most enigmatic and intractable subjects in biomedicine—neurodegeneration. Eponymic diseases of the nervous system that were until recently characterized by mechanistic ignorance and therapeutic nihilism are falling steadily to the power of molecular genetics, cell biology, bio...
متن کاملDefining a new role of GW182 in maintaining miRNA stability.
GW182 binds to Argonaute (AGO) proteins and has a central role in miRNA-mediated gene silencing. Using lentiviral shRNA-induced GW182 knockdown in HEK293 cells, this study identifies a new role of GW182 in regulating miRNA stability. Stably knocking down GW182 or its paralogue TNRC6B reduces transfected miRNA-mimic half-lives. Replenishment of GW182 family proteins, as well as one of its domain...
متن کاملDefining a novel role of GW182 in maintaining miRNA stability
As you will see, while the referees acknowledge that the finding that GW182 prevents miRNA degradation is potentially interesting, both referees 1 and 2 also point out that, as it stands, the manuscript is rather preliminary and requires significant strengthening before it can be considered for publication by EMBO reports. Both referees remark that endogenous miRNA levels need to be examined in...
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The present study aimed to identify the differentially expressed genes (DEGs) regulated by microRNA (miRNA)-221 and miRNA-222 that are associated with the resistance of breast cancer to fulvestrant. The GSE19777 transcription profile was downloaded from the Gene Expression Omnibus database, and includes data from three samples of antisense miRNA-221-transfected fulvestrant-resistant MCF7-FR bre...
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ژورنال
عنوان ژورنال: Circulation
سال: 2013
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.113.003058