Defining Emerging Roles for NF-κB in Antivirus Responses: Revisiting the Interferon-β Enhanceosome Paradigm
نویسندگان
چکیده
منابع مشابه
Defining Emerging Roles for NF-κB in Antivirus Responses: Revisiting the Interferon-β Enhanceosome Paradigm
Classic studies over the last two decades have made virus-induced activation of the mammalian interferon-b (ifnb) gene a prototype of eukaryotic gene regulation [1–6]. Indeed, the compact ,50 base-pair enhancer region upstream of the ifnb transcription start site is amongst the beststudied stretches of mammalian DNA, and its function in regulation of ifnb expression is considered a paradigm of ...
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(1) Department of Respiratory Medicine, National H Imperial College London, London, UK (2) MRC and Asthma UK Centre in Allergic Mechanism UK (3) Centre for Respiratory Infections, Imperial College L (4) Sezione di Malattie dell’Apparato Respiratorio, Cent Malattie Infiammatorie Croniche delle Vie Aeree Correlate dell’Apparato Respiratorio (CEMICEF), U Ferrara, Italy (5) Respiratory Pharmacology...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2011
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1002165