Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritis
نویسندگان
چکیده
منابع مشابه
Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritis
INTRODUCTION Inflammatory destructive arthritis, like rheumatoid arthritis (RA), is characterized by invasion of synovial fibroblasts (SF) into the articular cartilage and erosion of the underlying bone, leading to progressive joint destruction. Because fibroblast activation protein alpha (FAP) has been associated with cell migration and cell invasiveness, we studied the function of FAP in join...
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OBJECTIVE Neutrophil elastase accounts for the ability of some fresh rheumatoid synovial fluids to degrade cartilage matrix in vitro. The aim of this study was to determine if enzyme activity could result from depletion of synovial fluid inhibitors or protection of the enzyme from inhibition. METHODS The ability of synovial fluids to inhibit porcine pancreatic elastase was investigated togeth...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2015
ISSN: 1478-6354
DOI: 10.1186/s13075-015-0524-6