Defective Virions of Reovirus
نویسندگان
چکیده
منابع مشابه
Structure and function of adenovirus type 12 defective virions.
Purified human adenovirus type 12 preparations contain defective virions with a lighter density. These defective virions were isolated, and their biological functions and DNA were characterized. They can induce early and late antigens in infected cells and tumors in newborn hamsters with similar efficiency as complete virions. The majority of the DNA molecules from light virions contain deletio...
متن کاملSequence analysis of cDNA's derived from the RNA of Sindbis virions and of defective interfering particles.
Sindbis virus generates defective interfering (DI) particles during serial high-multiplicity passage in cultured cells. These DI particles inhibit the replication of infectious virus and can be an important factor in the establishment and maintenance of persistent infection in BHK cells. In an effort to understand how these DI particles are generated and how they interfere with the replication ...
متن کاملA DNA replication-positive mutant of simian virus 40 that is defective for transformation and the production of infectious virions.
Simian virus 40 (SV40) mutant 5002 carries base pair substitutions of C-5109----T and C-5082----T. These mutations lie in a region of the genome that encodes amino acids common to the large and small viral tumor antigens (T and t antigens, respectively) and result in amino acid substitutions of Leu-19----Phe and Pro-28----Ser. In contrast to wild-type SV40, which produces large plaques that are...
متن کاملUse of RT-Defective HIV Virions: New Tool to Evaluate Specific Response in Chronic Asymptomatic HIV-Infected Individuals
BACKGROUND Generation of new reagents that can be used to screen or monitor HIV-1-specific responses constituted an interesting field in the development of HIV vaccines to improve their efficacy. METHODS We have evaluated the specific T cell response against different types of NL4-3 virions (including NL4-3 aldrithiol-2 treated, NL4-3/ΔRT and R5 envelopes: NL4-3/ΔRT/ΔEnv[AC10] and NL4-3/ΔRT/Δ...
متن کاملIdentification and Characterization of a Double-Stranded RNA Reovirus Temperature-Sensitive Mutant Defective in Minor Core Protein m2
A newly identified temperature-sensitive mutant whose defect was mapped to the reovirus M1 gene (minor core protein m2) was studied to better understand the functions of this virion protein. Sequence determination of the M1 gene of this mutant (tsH11.2) revealed a predicted methionine-to-threonine alteration at amino acid 399 and a change from proline to histidine at amino acid 414. The mutant ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1970
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.6.2.226-236.1970